Trabajos de investigación

Propuesta de algoritmo global de tratamiento del hallux rigidus según la medicina basada en la evidencia https://doi.org/10.1016/j.recot.2014.05.004 Resumen Introducción El hallux rigidus es la artrosis más frecuente en el pie y tobillo. Existen numerosas revisiones respecto al tratamiento quirúrgico, pero escasas publicaciones que aborden la eficacia del tratamiento conservador. Objetivo Presentar un algoritmo global de…

Economic impact of periprosthetic hip fractures https://doi.org/10.1016/j.recot.2022.01.008 Introduction Hip arthroplasty is one of the most successful operations in orthopaedic surgery, and the number of both hip replacement and revision arthroplasties continues to increase year after year.1, 2 Due to the ageing population and the increasing functional demands of lifestyle, this trend is expected to continue rising.3 In general, few complications are…

Joint-Preserving Surgery in Varus Ankle Osteoarthritis Abstract Ankle deformity is a disabling condition especially if concomitant with osteoarthritis (OA). Varus ankle OA is one of the most common ankle OA deformities. This deformity usually leads to unequal load distribution in the ankle joint and decreases joint contact surface area, leading to a progressive degenerative arthritic…

New Sub-Classification of Vancouver B2 Periprosthetic Hip Fractures According to Fracture Pattern Abstract Introduction There is currently a debate on whether all Vancouver type B2 (V-B2) periprosthetic hip fractures (PPHF) should be revised. Vancouver classification takes into account fracture location, implant stability and bone stock, but it does not distinguish between fracture patterns. The aim of our…

HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas PMID: 30017537 DOI: 10.1016/j.ygyno.2018.07.007 Abstract Objective: Around 70% of uterine leiomyomas show MED12 mutations while overexpression of HMGA2 mRNA is also highly frequent in fibroids. However, previous studies suggested that alterations in both genes are mutually exclusive. In the present study, we searched for mutation in MED12 and analyzed…

Stem Cell Growth and Differentiation in Organ Culture: New Insights for Uterine Fibroid Treatment Biomedicines 2022, 10(7), 1542; https://doi.org/10.3390/biomedicines10071542 Abstract Organ culture allows for the understanding of normal and tumor cell biology, and tissues generally remain viable for 5–7 days. Strikingly, we determined that myometrial and MED12 mutant leiomyoma cells repopulated cell-depleted tissue slices after 20 days of culture. Using…

Twin pregnancy with a complete hydatidiform mole and co-existing fetus following in-vitro fertilization: case report PMID: 10548646 DOI: 10.1093/humrep/14.11.2905 Abstract Hydatidiform mole with a co-existing live fetus is a rare event. We report the case of a 41 year old Caucasian woman who attended for in-vitro fertilization. Three embryos, containing two apparently normal pronuclei, were transferred into…

Neurotensin and Neurotensin Receptor 1 Expression in Human Myometrium and Uterine Leiomyomas DOI:10.1095/biolreprod.110.084962 Abstract and Figures Leiomyomas or fibroids are the most frequently diagnosed tumors of the female genital tract, and their growth seems to be steroid-hormone dependent by a yet undetermined cellular and molecular mechanism. Sexual hormones induce the secretion of growth factor peptides…

Differentially regulated expression of neurokinin B (NKB)/NK3 receptor system in uterine leiomyomata PMID: 23656837 DOI: 10.1093/humrep/det128 Abstract Study question: Are the vasoactive peptide neurokinin B (NKB) and its preferred NK3 receptor (NK3R) differentially expressed in leiomyomas compared with normal myometrium? Summary answer: In leiomyomas, NKB is up-regulated and delocalized, while its preferred NK3R is also differentially regulated. What is…

A high-throughput open-array qPCR gene panel to identify housekeeping genes suitable for myometrium and leiomyoma expression analysis PMID: 24768852 DOI: 10.1016/j.ygyno.2014.04.012 Abstract Objective: To evaluate 51 different housekeeping genes for their use as internal standards in myometrial and matched leiomyoma samples in proliferative and secretory phases. Methods: RNA from 6 myometrium and matched leiomyoma samples was obtained from pre-menopausal…

Comparison of flipped learning and traditional lecture method for teaching digestive system diseases in undergraduate medicine: A prospective non-randomized controlled trial PMID: 33502276 DOI: 10.1080/0142159X.2020.1867312 Abstract Introduction: This study examined the effects of a large-scale flipped learning (FL) approach in an undergraduate course of Digestive System Diseases. Methods: This prospective non-randomized trial recruited 404 students over three academic years.…

Mesenteric closure in laparoscopic gastric bypass: surgical technique and literature review. PMID: 17785141 DOI: 10.1016/s0009-739x(07)71673-1 Free article Abstract Despite the advantages offered by laparoscopy in bariatric surgery, the incidence of a new complication that was uncommon in the previous era of open surgery–internal hernias–has increased. Most publications in the literature dealing with internal hernia describe the incidence…

A revolutionary design change to improve stapler safety PMID: 23138890 DOI: 10.1007/s11695-012-0792-z Abstract Background: Postoperative staple line leaks and bleeding are the most common reasons for complications in surgical procedures that involve organ resection, such as sleeve gastrectomy. Increasing the safety of these operations requires improving the instruments (endostaplers or endocutters) used for stapling and sectioning the tissues.…